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It runs just smoothly with disabling Physx helps improving performance.

Another trick is to Locate the Directory: /home/your_user_account/.wine/drive_c/users/your_user_account/Local Settings/Applications/Ascaron Entertainment/Sacred 2 
Create a NEW file named <o­ptionsCustom.txt> and write these lines:

settings.enableMobilitySupport = 0 
settings.usePhysHW = 1 

Save and quit.

Open Configure Wine and select the tab named "Libraries".

Set an override for the library openal32, and select from the Modify Menu the entry Native then Builtin.

LATEST WINE IS REQUIRED 1.5.XXX above

OS X 10.6.8 ATI card Redeon 256 Mb