Hi again.
The AppDB-page is the page I linked you to, containing the HowTo.
1. Open PlayOnLinux.
2. Press "Tools"->"Manage Wine-version" and install 1.1.27 if not already installed. Close that window.
3. Press "Install", "Install a .pol package or an unsupported application", "Manual Installation", "New prefix" and choose Wine-version 1.1.27.
4. Locate your installation-file. (Probably on a CD)
5. Install as usual.
6. Yes, you would want a shortcut. Locate the right file and give it a proper name.
7. Right-click your shortcut in PlayOnLinux and choose "Registry Editor".
8. Locate HKEY_CURRENT_USER->Software->Direct3D->OffscreenRenderingMode and set it to fbo. (
Guide about the registry)
9. Open your filebrowser and locate the folder
~/.PlayOnLinux/configurations/installed/
10. Open the script called what your shortcut for the game is called. (Probably Titan Quest)
11. On the last line add a space and a &. (Looking somthing like this:
wine "Titan Quest" $@ &)
12. Add these lines after that script:
sleep 5
taskset -p 1 `pidof Titan\\ Quest.exe`
13. Save the script and close all windows except the PlayOnLinux-window.
14. Right-click the shortcut and select "Go to the applications directory".
15. A file-browser will open, now rename the "Videos" directory to whatever you like.
16. Start the game and try to find the best configuration with settings you can find. (May be high settings, may be low settings)
17. Save your game often, it will probably crash one in a while.
Good luck! :)