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I finally got Diablo 3 running following the link below, but the framerate isn't working well.  If I run the game in fullscreen mode, it's completely unusably.  It seems like events take 30 seconds to process.  However, if I run the game in windowed mode, I get like 20fps, which is much better, but I'm hoping for a little better.  According to the post, I can run the game in OpenGL by adding an argument, but I don't know where the arguments can be specified in the playonlinux interface.  Is that under one of the specific tabs?  

You have to update PlayOnLinux to the latest version

I downloaded the development version and now see the arguments field, where I've added the -opengl flag. However, the gameplay is still incredibly slow. If I run it game in a virtual window, I get about 15 fps, which drops to about 5fps when get into combat. If I don't use a virtual desktop, the game is completely unplayable. The crows at the start screen don't animate and the sound is choppy. I can load the options menu, but every click takes about 10-30 seconds to process. Why would running in windowed mode speed things up? And why is it so slow in windowed mode even with -opengl?

I'm running Ubuntu 12.04 in the gnome (no effects) session. I'm using the proprietary nVidia drivers with an 8800 GTS.

Edited by strattonbrazil

I'll pursue this in another thread.

Just a note. I tried setting the render target to "backbuffer" as I assume it was using "fbo" and I got about 30-35 fps, but now have a graphical artifact, where the ground underneath the character is totally black.