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I'll say it almost works. One problem is with the File Edit menu, it doesn't work. Another problem is with sound, when I could choose which output device to use, there was sound, but when I quit the program and re-opened, I couldn't choose the output device, and it showed error that it couldn't open last session output driver, and now there's no sound. (And since I can't access the Preferences in Edit menu, I can't do anything).

Same issue from FunnyGames on my system with reason 5. Menus are visible but a click has no effect. The next is that the sound driver is not loadet in wine version 1.4-1.5 and can not loadet without a menu. With older versions from wine is in reason 5 the system default soundcard available.

Wine version: 1.5.3
Distribution: Mint
Distribution version: 13 (maya) x64
Graphics card: GeForce 8600 GT/PCIe
Graphics card driver: 295.49

Hello!
An update!!

Well, now it saves the sound driver. So I can work with it! :)
HOWEVER!! It still has problems with menu. But I can use shortcuts and it does what I ask for. (Ctrl + O = Open, Ctrl + N = New, etc...)

Wine version: 1.5.13
Distribution: Fedora
Distribution version: 17 (Beefy Miracle) x64
Graphics card: Nvidia GTX 560 Ti
Graphics card driver: 304.60

So far, for about the last 2 years, I have never had a problem installing or using reason in full capacity with whatever version of wine was the newest. Even upgrading Wine, it still worked with no problems, except that menu issue. Im currently working VERY hard to correct this, as its really the only thing keeping it from running all kinds of sexy. I have been using reason since 1.0.1.. like, almost 10 years ago, and this is a deal sealer now that its working at 98% perfect. I actually notice lower CPU usage with the newest version of wine, no patches, and POL. Ableton works very well, too.