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I recently got Serious Sam TFE GOG edition. Running fine on Playonlinux using but graphic is buggy. I see through the objects.

http://i.imgur.com/soONYIw.jpg

Playing with the game options made no difference. Im on OpenGL.

Linux version: Xubuntu 16.04

Version de POL: 4.2.10

Full computer specs: Intel Core i3-4170, Intel HD Graphics 4400, Mesa Drivers 17.0.7

First thing first... make sure to update to the newest PlayOnLinux 4.2.12

What version of Wine are you using?

Any time I've seen graphical artifacts like that... its because of direct X.  Try installing a few other Direct X packages or even try installing dxfullsetup.

I did everything you mention. Updated playonlinux and went full dx setup but still the same. I tried several wine versions 1.6.2, 1.3.5, 2.16-staring. No difference. I think it's maybe a driver issue since nvidia users had those glitches on HD version.
 

Seems the game has an OpenGL renderer. Did you try it ? I should read more carefully. I do not understand why the OpenGL mode does not work.

PS : installing d3d dll won't change anything in OpenGL mode ;)

Edited by ImperatorS79

Maybe try Direct X mode in-game... but yes, may be a driver issue.