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as you now many bugs are depends on compiz
i've tried today one thing and its worked, so may be you'll include it in the next versions as an option
I added two commands to launch POL script to switch compiz off before wine application start and to enable it after it finished.

#!/bin/bash
export WINEPREFIX="/home/chain/.PlayOnLinux/wineprefix/A9Cad"
export WINEDEBUG="-all"
cd "/home/chain/.PlayOnLinux/wineprefix/A9Cad/drive_c/Program Files/A9Tech/A9CAD"
metacity --replace; wine "a9cad.exe" $@; compiz --replace

work nice for me

so as not all users used compiz, thank it can be an optional feature.

And if you use KDE ?

yep, sorry forgot that kde didn't use metacity...