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The config tool runs fine, it starts without any issues. Changing the settings there didn't help though, the demo still crashes.

Just purchased ME3, installing it now.

It works! So apparently the demo won't start, but the full game starts up just fine . Thanks for all the help!

EDIT: The game runs quite well, although Origin crashes frequently, causing ME3 to close. Origin really sucks

Edited by leoworm

Awesome!  Glad you took the risk and it worked!
I get the Origin crashes too, but found a trick

When Origin Crashes, just Alt+Tab back to PlayOnLinux and launch Origin again, then go back to Mass Effect 3 and continue playing

When Origin Crashes, just Alt+Tab back to PlayOnLinux and launch Origin again, then go back to Mass Effect 3 and continue playing

 

Quote from booman

I love you 

Edited by leoworm

Settle down 
As you can see Wine has it's "bugs" but games WILL work.
This is my experience with a lot of games I have tested.  Setup PlayOnLinux, Wine and packages, install game, configure and play.  Some crash, most run fine.

I'm thankful for Wine developers and PlayOnLinux developers.  They are the reason I've stuck with Linux since I'm a huge gamer.

Please mark your post as "solved"
Feel free to donate to PlayOnLinux so we can keep playing newer games.

By the way, I found a quicker way to install Origin instead of killing the process.
I posted all of the new steps in this Medal Of Honor Guide

Basically, Origin isn't crashing after the installation, its waiting...
But you have to adjust the permissions for the Origin folder and delete the igoproxy.exe files and Origin will appear with a login screen.

For anyone interested, you can fix the crashing issue permanently by disabling cloud saving in Origin

Ooo, thanks for the tip!  I never thought of that