Hello,
First of all, the hardware/OS setup: this is a Dell M3800 which has two GPUs, one "bundled" with the (Haswell) CPU and an NVidia; from lspci:
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00:02.0 VGA compatible controller: Intel Corporation 4th Gen Core Processor Integrated Graphics Controller (rev 06)
[...]02:00.0 3D controller: NVIDIA Corporation GK107GLM [Quadro K1100M] (rev a1)
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I use NVidia's proprietary X server, version 346.59 (from updates).
This X server allows me to switch between the two GPUs; my GPU of choice is the Intel one, since this machine is mostly used for development (and by the way the screen is not the 4k one; resolution is a "measly" 1920x1080)... However, while it poses no problem for NWN *1* (always from GoG), NWN 2 complains about less than 128 MiB available. Problem solved by just switching to the NVidia GPU...
But then the problem is with the sound. I had no sound at all to begin with. When launching playonlinux from the CLI I see this:
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ALSA lib conf.c:3325:(snd_config_hooks_call) Cannot open shared library libasound_module_conf_pulse.so
ALSA lib pcm.c:2239:(snd_pcm_open_noupdate) Unknown PCM default
ALSA lib pcm_dsnoop.c:618:(snd_pcm_dsnoop_open) unable to open slave
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The solution I found was to run winecfg for this prefix and explicitly select the audio device instead of relying on the system default... And yes, there _is_ a libasound_module_conf_pulse.so (two, in fact, in /usr/lib/{i386,x86_64]-linux-gnu/alsa-lib).
Strangely enough, the installation of GoG NWN1 (Diamond edition) suffers none of those two problems; although admittedly the game is much older and less demanding, I also see that the version of wine it requires is in fact more recent...