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Hi!!!
I have next problem:

I can`t run any 64bit app in PlayOnLinux with optirun, even I can`t "reboot windows" or run "task manager". However without optirun it works fine.

Here is terminal`s output:

wine client error:0: version mismatch 454/449.
Your wine binary was not upgraded correctly,
or you have an older one somewhere in your PATH.
Or maybe the wrong wineserver is still running?
err:wineboot:main failed to restart 64-bit L"C:\\windows\\system32\\wineboot.exe", err 1359

I tried to reboot and reinstall wine several times and it didn`t help me.

Sorry for my bad English.
 

 

That really is strange. Just so that I understand correctly, this ONLY does this when you run optirun? Did it work before? To be honest, I never run 64-bit installations of programs through POL, as I usually have a bad experience, but that is really odd that it is giving a Wine version mismatch when running optirun only. 

version mismatch is between Wine client and Wine server, that most likely mean there's some Wine server process of a different version still running.

Why it would happen when running under optirun is less clear...

Did it work before? 

Quote from RoninDusette

 I didn`t run it earlier, so I don`t know.

Wine server process of a different version still running.

Quote from petch 

wineserver -k #has no effect
ps aux | grep -P "wine|\.exe" #returns nothing

And one more: In 64-bit apps "System" version of wine is missing (My os is 64-bit, I check it).

System 64bit Wine is not supported, as it seems not two distros decided to compile it the same way.

So System version is assumed to be 32bit.

 

I have exactly the same problem. I have no idea why launching a 64-bit application fails with optirun/primusrun.

The error description seems not to be valid because I have absolutely no Wine processes such as exe's, wineserver or any wine-related thing running on my system. I have checked this so many times that even suggesting this as a solution is completely irrelevant and off-topic in my case.

Running 64-bit application with Intel card works fine without issues.

The same behavior occurs with multiple 64-bit Playonlinux-based Wine prefixes. 32-bit prefixes are not affected in any way.

I suspect this is a driver issue. That's why I checked my Nvidia drivers. I have both 64-bit and 32-bit Nvidia drivers installed.

I am able to run 64-bit KDE environment purely with Nvidia card only.

The relevant Playonlinux output states as follows:

wine client error:0: version mismatch 490/489.
Your wine binary was not upgraded correctly,
or you have an older one somewhere in your PATH.
Or maybe the wrong wineserver is still running?
err:winecfg:WinMain failed to restart 64-bit L"C:\\windows\\system32\\winecfg.exe", err 1359
Application tried to create a window, but no driver could be loaded.
The explorer process failed to start.
[POL_Wine] Message: Wine return: 0

The error message is always the same (eg. references "mismatch 490/489" etc.)

It doesn't really matter whichever Wine version I try to use on Playonlinux. The error message stays the same whether I use 64-bit Wine 1.8, 1.7.55, 1.7.34 or any version installed from your official Wine version pool.

Running 32-bit Wine application with optirun works fine.

I've reached a dead-end. I doubt I can solve this problem on my own which is why I need help with it.

Edited by Fincer