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I am running PlayOnLinux on Gutsy, 64 bit. When trying to install Galactic Civ 2 using PlayOnLinux > Install > and then Live Install (because there is no script for it), I run into two issues:

1. No wineprefix is created for it on the main PlayOnLinux interface GUI, nor any other game I try to install this way, so using the Tools is impossible.

2. This game is a 2 CD install. When it gets to the point where you must eject the cdrom, it says, "Insert CD #2, Source Pathname: Z:\media\cdrom0". The system wont allow me to eject the drive normally. Typing "wine eject" into the terminal comes back with "err:advapi:service_control_dispatcher pipe connect failed"

Any help on this would be appreciated.

I don't mess with dvd's mostly because of drm. I use Steam for most of my games.

I recommend doing a manual installation, this way you can choose the name of the wineprefix, the libraries you want to install and the version of Wine you want.

I do manual installations for every game. It just gives me more control.

Also, try copying all the contents from both CD's into a single folder on the desktop.
This way when you do the manual installation, you can select the "setup.exe" to start the installation.