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I tried upgrading from wine 1.7.10 to wine 1.7.11 but it still freezes shortly after loading the saved game.

[02/01/14 03:36:39] - Running wine-1.7.10 Launcher.exe (Working directory : /home/steve7233/.PlayOnLinux/wineprefix/Civ5/drive_c/Program Files/Steam/SteamApps/common/Sid Meier's Civilization V)
[0201/033654:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/033654:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
Setting breakpad minidump AppID = 8930
Steam_SetMinidumpSteamID:  Caching Steam ID:  76561198061982426 [API loaded no]
[0201/033812:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/033812:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
wine: Unhandled page fault on read access to 0x0000000c at address 0x7e7461d8 (thread 0059), starting debugger...
fixme:advapi:EventRegister {47a9201e-73b0-42ce-9821-7e134361bc6f}, 0x1003c780, 0x10092f40, 0x10092f38
fixme:advapi:EventRegister {58a9201e-73b0-42ce-9821-7e134361bc70}, 0x1003c780, 0x10092f78, 0x10092f70
fixme:advapi:EventRegister {3fa9201e-73b0-43fe-9821-7e145359bc6f}, 0x1003c780, 0x10092f08, 0x10092f00
fixme:advapi:EventRegister {1432afee-73b0-42ce-9821-7e134361b433}, 0x1003c780, 0x10092fb0, 0x10092fa8
fixme:advapi:EventRegister {4372afee-73b0-42ce-9821-7e134361b519}, 0x1003c780, 0x10092fe8, 0x10092fe0
[0201/034729:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/034729:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
[0201/034732:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/034732:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
[0201/034737:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/034737:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
[0201/034742:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/034742:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
[0201/034748:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/034748:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
fixme:imm:ImmReleaseContext ((nil), (nil)): stub
fixme:advapi:EventUnregister deadbeef: stub
fixme:advapi:EventUnregister deadbeef: stub
fixme:advapi:EventUnregister deadbeef: stub
fixme:advapi:EventUnregister deadbeef: stub
fixme:advapi:EventUnregister deadbeef: stub
[02/01/14 03:48:12] - Running wine-1.7.11 Launcher.exe (Working directory : /home/steve7233/.PlayOnLinux/wineprefix/Civ5/drive_c/Program Files/Steam/SteamApps/common/Sid Meier's Civilization V)
Setting breakpad minidump AppID = 8930
Steam_SetMinidumpSteamID:  Caching Steam ID:  76561198061982426 [API loaded no]
[0201/035010:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/035010:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
ALSA lib pcm.c:7843:(snd_pcm_recover) underrun occurred
wine: Unhandled page fault on read access to 0x0000000c at address 0x7e7461d8 (thread 01c2), starting debugger...
fixme:advapi:EventRegister {47a9201e-73b0-42ce-9821-7e134361bc6f}, 0x1003c780, 0x10092f40, 0x10092f38
fixme:advapi:EventRegister {58a9201e-73b0-42ce-9821-7e134361bc70}, 0x1003c780, 0x10092f78, 0x10092f70
fixme:advapi:EventRegister {3fa9201e-73b0-43fe-9821-7e145359bc6f}, 0x1003c780, 0x10092f08, 0x10092f00
fixme:advapi:EventRegister {1432afee-73b0-42ce-9821-7e134361b433}, 0x1003c780, 0x10092fb0, 0x10092fa8
fixme:advapi:EventRegister {4372afee-73b0-42ce-9821-7e134361b519}, 0x1003c780, 0x10092fe8, 0x10092fe0
[0201/040431:ERROR:resource_bundle.cc(417)] Failed to load C:\Program Files\Steam\bin\chrome.pak
Some features may not be available.
[0201/040431:ERROR:network_change_notifier_win.cc(126)] WSALookupServiceBegin failed with: 8

I solved it when I remembered that 'WSALookupServiceBegin failed with: 8', refers to an internet problem. I realized that the Steam Overlay must be bugged. I went into the Steam application, selected Civ 5 with a right click, selected properties, general tab and deselected use the steam overlay. The game works now. Steam for Windows and Mac gets bugged a lot to the point that wine has problems. You'd think Valve would be more careful since they obviously know that a lot of their players use Linux/wine. They even ported Steam to Linux via Steam for Linux.